Hydrogen-Bonded DeUG·DAN Heterocomplex: Structure and Stability and a Scalable Synthesis of DeUG with Reactive Functionality
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A convenient, scalable synthesis of the supramolecular building block 7-deazaguanine-based urea (DeUG) is reported. Incorporation of reactive moieties (DeUG azide 10 and alkyne 11 for copper-catalyzed azide-alkyne cycloadditions, “click chemistry”) and a demonstration of transesterification (DeUG glycol, 12) highlights the versatility. X-ray structures of DeUG and a DeUG·DAN heterocomplex were obtained. Kassoc for the 1·2 heterocomplex was estimated to be 2 × 108 M−1 in chloroform.
创建时间：
2009-01-01
