Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we induced chromosome mis-segregation in non-tran

NIAID Data Ecosystem00

Crystal structure of AfOgg1-K122S mutant bound to 8-OG DNA duplex in an intermediate state

DNA损伤修复

DNA复合物

Crystal structure of AfOgg1-K122S mutant bound to 8-OG DNA duplex in an intermediate state

NIAID Data Ecosystem00

Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA replication.

DNA损伤修复机制

核酸碱基配对动力学

During DNA replication, mutations occur when an incorrect dNTP is incorporated opposite a carcinogen-modified nucleotide. We have probed the structures of the interaction between O 6-methylguanine ( O

PubMed Central1997-08-15 更新00

Aberrant termination of equal sister chromatid exchange underlies BRCA1-associated microhomology-mediated tandem duplication

癌症基因组数据

DNA损伤修复机制

Typical ~10-kilobase tandem duplications associated with Brca1 -deficient tumors were revealed by analysis of human cancer genome sequences, but the present underlying mechanisms remain defect

Zenodo2025-06-10 更新00

X-ray structure of AlkB protein bound to dsDNA containing 1meA/A with cofactors

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