The proportion of embryos with macroscopic phenotypic changes following tamoxifen administration at E12.5.

Embryonic day (E) indicate day of analysis. The morning and afternoon of E16.5 is indicated as am and pm, respectively. Ctrl and cKO are tamoxifen-treated embryos with genotypes F/F and F/F;Cre, respectively. Animals with macroscopic phenotypic changes are indicated as number of animals (n) as well as % of animals. The total number of embryos analyzed is indicated within brackets. Phenotypic changes include edema, hemorrhage and reduced crown-rump length.