Files for the manuscript "Genome- and Transcriptome-wide association meta-analysis reveals new insights into genes affecting coronary and peripheral artery disease"

MS Michael Rode1 ¶ , PhD Maciej Rosolowski1¶, MS Katrin Horn1,2, Sylvia Henger1, MD Andrej Teren2,3, PhD Kerstin Wirkner2, MD Joachim Thiery 2,4, MD Markus Loeffler1,2, PhD Janne Pott1,5, PhD Holger Kirsten1,2, PhD Markus Scholz1,2*

1 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany

2 LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany

3 Department of Cardiology, Angiology and Intensive Care, Klinikum Lippe, Detmold, Germany

4 Medical Campus Kiel, University Hospital Schleswig-Holstein, Kiel, Germany

5 University of Cambridge, MRC Biostatistics Unit, Cambridge, United Kingdom

¶ These authors contributed equally to this work.

* Corresponding author E-mail: [e-mail]

GWAMA_ABI_summarystat.csv.gz

contains summary statistics from meta-analysis of GWAS of the Adult and Heart studies. Columns are annotated in Supplementary Table 10.

S-PrediXcan_results.xlsx

contains the results (z-scores and p-values) of S-PrediXcan of the artery tissue (result with the smallest p-value of the analyses of aorta, coronary and tibial artery tissues), and whole blood. Columns starting with "TWAMA_" contain the t-statistics and p-values of TWAMA (meta-analysis of measured gene expression of the Adult and Heart studies). The results of S-PrediXcan and of TWAMA were merged by gene symbol. When multiple gene expression probes for a gene were present in the TWAMA results, the probe with the smallest p-value was selected. A part of these results, containing only the nominally significant genes in at least one artery tissue and in whole blood is presented in Supplementary Table 5.

TWAMA_results.xlsx

contains complete results of TWAMA (meta-analysis of measured gene expression of the Adult and Heart studies). A part of these results, containing only the significant probes (FDR adjusted p-value in column "padj_fixed_filt_I2") is presented in Supplementary Table 7. The columns are:

PROBE_ID

Probe ID of measured gene expression TWAMA

beta_adult

Regression coefficient for ABI in the Adult study

beta_heart

Regression coefficient for ABI in the Heart study

SE_adult

Standard error of the regression coefficient for ABI in the Adult study

SE_heart

Standard error of the regression coefficient for ABI in the Heart study

CI.L_adult

Lower limit of the 95% confidence intervall of the regression coefficient for ABI in the Adult study

CI.L_heart

Lower limit of the 95% confidence intervall of the regression coefficient for ABI in the Heart study

CI.R_adult

Upper limit of the 95% confidence intervall of the regression coefficient for ABI in the Adult study

CI.R_heart

Upper limit of the 95% confidence intervall of the regression coefficient for ABI in the Heart study

pval_adult

P-value for the regression coefficient for ABI in the Adult study

pval_heart

P-value for the regression coefficient for ABI in the Adult study

TE.fixed

Fixed effect estimate of meta-analysis of the regression coefficients for ABI in the Adult and Heart studies

seTE.fixed

Standard error of the fixed effect estimate in meta-analysis of the regression coefficients for ABI in the Adult and Heart studies

pval.fixed

P-value fixed effect meta-analysis

TE.random

Random effects estimate of meta-analysis of the regression coefficients for ABI in the Adult and Heart studies

seTE.random

Standard error of the random effect estimate in meta-analysis of the regression coefficients for ABI in the Adult and Heart studies

pval.random

P-value random effects meta-analysis

Q

Cohran's Q

pval.Q

P-value Cohran's Q

I2

I2

tau2

Tau2

se.tau2

Standard error of tau2

padj_fixed

Adjusted p-value of the fixed effect. The adjustment was for the false discovery rate (FDR) using the method of Benjamini and Hochberg.

padj_fixed_filt_I2

Adjusted p-value of the fixed effect estimate. The adjustment using the method of Benjamini and Hochberg was applied to p-values of probes that met I2 < 0.5

padj_random

Adjusted p-value of the random effects estimate.  The adjustment was for the false discovery rate (FDR) using the method of Benjamini and Hochberg.

symbol_INGENUITY

Gene symbol INGENUITY

synonyms_INGENUITY

Synonyms INGENUITY

description_INGENUITY

Gene description INGENUITY