Tau pathology is not significantly reduced by LXR activation.

(A-B) Presence of aggregated phospho-tau in brains of treated and untreated mice groups was evaluated by immunohistochemistry with anti-phospho-tau antibody (AT-8). (C-D) No significant changes were found in the quantification of aggregated phospho-tau occupied area within the hippocampus or cortex in treated mice. Data were expressed as mean ± S.E.M. Statistical analysis was done by one way ANOVA followed by Tukey's multiple comparison test. n = 4 Females per 3xTg-AD group.