Systematic mapping of 3D enhancer interactions reveals lineage specific regulatory networks during early mouse developmental decisions [ATAC-Seq]

To model and characterize the chromatin regulatory landscape of the very first developmental cell fates, we made use of three previously derived and well-characterized Trophoblast Stem Cell (TSCs), Embryonic Stem Cell (ESC) and Extra Embryonic Stem Cell lines (XENs) We performed ATAC to map accessible regions (AR) in enhancer and promoter regions in ESC, TSC, XEN and EPISC Overall design: Characterization of AR with ATAC-seq for all cell types.