Transcriptome analysis of Mast4 KO mouse incisor and testis

Microtubule-associated serine/threonine kinase family member 4 (Mast4) knockout (KO) mice showed abnormal incisor development with weak hardness as the apical bud was reduced and preameloblasts were shifted to the apical side, resulting in Amelogenesis Imperfecta. Mast4 KO incisors showed abnormal enamel maturation, and stem cell maintenance was inhibited as amelogenesis accelerated. In addition, Mast4 KO testis showed reduced size and sperm number. KO testes also showed morphology of Sertoli-cell-only (SCO) syndrome. Both organs may have stem cell maintenance problem.Here we provide transcriptome seqeuncing data of incisors and testes from 6w old MAST 4 KO and WT mice. Samples for incisors were gathered from secretory ameloblast region and apical bud region separately.