Loss of Bap1 leads to an increased global methylation and decrease in H3K27AC enhancer marks around key lineage commitment genes in Xenopus laevis embryos [ChIP-seq]
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资源简介：
We performed morpholino-mediated knockdown of Bap1 protein expression in Xenopus laevis developing embryos, and analyzed inhibiting and activating histone marks . We find that inhibition of Bap1 leads to decrease in H3K27AC activating makrs around lineage commitment genes, and increased global methylation. Control and Bap1-depleted stage 12 frog embryos were analyzed by ChIP-seq for expression of H3K27AC, H3K27me3, H2Aub and H3K4me3 histone marks.
创建时间：
2019-10-01
