Differential expression and pathway enrichment in neutrophils treated with Ruxolitinib and vehicle. Differential expression and pathway enrichment in neutrophils treated with Ruxolitinib and vehicle

We report the effect of rexolitinib on neutrophil function, by extracting mouse bone marrow neutrophils, and after treatment with Ruxolitinib and vehicle, extracting neutrophil RNA from each group for RNA-seq. Finally, we show that Ruxolitinib produces functional effects on neutrophils mainly through inflammatory signaling pathways, amplifying the immune effects of neutrophils in an inflammatory environment and accelerating neutrophil death. Overall design: The changes of Neutrophil RNA expression in Ruxolitinib-treated and vehicle treated groups were detected