Gene expression changes of ethylenediamine dihydrochloride-induced in renal cortex of rats

This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with ethylenediamine dihydrochloride, and the gene expression profiles of renal cortex were analyzed using custom microarrays.本研究旨在开发一种基于致癌物（carcinogens）染毒大鼠基因表达谱（gene expression profile）的短期高精度肾脏致癌性（renal carcinogenicity）预测方法。本研究对雄性SD（Sprague-Dawley）大鼠开展了为期28天的重复给药实验，染毒试剂为乙二胺二盐酸盐（ethylenediamine dihydrochloride）；随后采用定制基因芯片（custom microarrays）对大鼠肾皮质（renal cortex）的基因表达谱进行分析。