Myositis TCR beta adaptive immune receptor repertoires

Objectives: To characterize the T cell receptor (TCRb) repertoire in peripheral blood and muscle tissues of treatment naive patients with newly diagnosed idiopathic inflammatory myopathies (IIMs).Methods: High throughput RNA sequencing of the TCRb chain was performed in peripheral blood and muscle tissue in twenty newly-diagnosed treatment-naive IIM patients and healthy controls. Results thereof were correlated with markers of disease activity.