BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (Microarray)
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184587
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We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells. We used microarrary to compare transcriptional profile of sgNTC ('Spike_Smarcd2')- or sgSmarcd2-transduced P14 cells from the dual-color transfer system at day 7.5 post-infection from spleen; we used microarrary to compare transcriptional profile of sgNTC ('Spike_Arid1a')- or sgArid1a-transduced P14 cells from the dual-color transfer system at day 7.5 post-infection from spleen
创建时间：
2022-07-08
