Qi et al., WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
收藏NIAID Data Ecosystem2026-03-13 收录
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资源简介：
In this article, Qi et al. uncover a role of WWC family proteins in transducing signals from Hippo kinases to LATS1/2. Based on this mechanism, a SuperHippo minigene has been engineered to robustly and specifically activate LATS1/2, which in turn inhibit YAP/TAZ oncoproteins and tumorigenesis in multiple models.
创建时间：
2022-03-08
