Pd-Catalyzed α‑Selective C–H Functionalization of Olefins: En Route to 4‑Imino-β-Lactams

Pd-catalyzed α-olefinic C–H activation of simple α,β-unsaturated olefins has been developed. 4-imino-β-lactam derivatives were readily synthesized via activation of α-olefinic C–H bonds with excellent cis stereoselectivity. A wide range of heterocycles at the β-position are compatible with this reaction. The product of 4-imino-β-lactam derivatives can be readily converted to 2-aminoquinoline which exists extensively in pharmaceutical drugs and natural products.