Sexually dimorphic ozone-induced changes in fetal rat hypothalamus

IUGR is associated with an increased risk of obesity in offspring, which is likely driven in part by reprogramming of the hypothalamus due to suboptimal nutrition and hypoxia during development. As such, we performed mRNA-seq on whole hypothalamic tissue to identify altered expression of genes in our model of IUGR and to identify major pathways that could be associated with fetal undernutrition near term.宫内生长受限（Intrauterine Growth Restriction，IUGR）与子代肥胖风险升高显著相关，其潜在驱动因素之一为发育阶段营养不足与缺氧引发的下丘脑重编程。鉴此，我们对全下丘脑组织开展了mRNA测序（mRNA-seq），以期在本研究的IUGR模型中筛选出表达异常的基因，并识别与足月胎儿子宫营养不良相关的主要通路。