The enormous toll on human life during the 1918–1919 Spanish influenza pandemic is a constant reminder of the potential lethality of influenza viruses. With the declaration by the World Health Organiz
aMean fold-change in IC50 compared to that of WT virus. bDetermined by the Kaplan-Meier method (Mantel-Haenszel test). cDetermined once daily for 14 days of observation based on the scoring system des
In this study, viruses isolated from healthy patients undergoing fatal influenza infection and non-deceased patients cohorts were sequenced to identify viral genetic determinants contributing to infec
Pandemic (H1N1) 2009 influenza virus spread throughout the world since most people did not have immunity against the virus. In the post pandemic phase when many humans might possess immunity against t
Highly pathogenic avian influenza viruses (HPAIVs) frequently receive global attention as threats to public health. The NS1 protein is a key virulence factor known to impair host antiviral responses.
