2-hydroxy-1,4-naphthoquinones with 3-alkyldiarylether groups: synthesis and Plasmodium falciparum inhibitory activity - Supplementary data

Synthesis of 4-hydroxyphenyl esters <strong>20c</strong> and <strong>20d</strong> 
 General method for the synthesis of the phenoxyphenyl esters (<strong>22a-d)</strong>  
 General method for the synthesis of the phenoxyphenyl acids<strong> (23a-d)</strong> 
 Characterization of<strong> 3b</strong>, <strong>3c,</strong> and<strong> 3g-j </strong> 
 Ester reduction to synthesize<strong> 28a </strong>and <strong>28b</strong> 
 Carboxylic acid reduction to synthesize 2-(4-(4-fluorophenoxy)phenyl)ethan-1-ol<strong> (28c)</strong> 
 Further information from the oxidation and reductive alkylation reactions to obtain<strong> 3h</strong>, <strong>3i</strong>, and<strong> 3k</strong>  
 Parasite culture and assay information  
 References 
 1H and 13C NMR spectra for all compounds 
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