Isoformic PD-1 is tumorigenic in hepatocellular carcinoma through seemingly exhausted aß T cells

Purpose: To investigate functional differences between ?42PD-1+ and PD-1+ T cells in HCC patients Methods: ?42PD-1+, PD-1+ T and ?42PD-1-PD-1- T cells were isolated by cell sorting from HCC patient's PBMCs and performed the BD Rhapsody single-cell RNA sequencing with focus on 259 T cell-relevant transcripts Results: Data were obtained from 3 separate T cell subsets, including 3,758 PD-1+, 3,242 ?42PD-1+ and 4,626 ?42PD-1-PD-1- T cells, respectively. Overall design: Comparison of T cell-relevant transcripts between ?42PD-1+, PD-1+ T and ?42PD-1-PD-1- T cell subsets