Multivariable proportional-hazards analysis of 10 year survival risk^*.

*Results were calculated using the dataset of van de Vijver, et al. using overall survival as the endpoint. Similar results were obtained for the same multivariable analysis using relapse as the endpoint, 3D signature Hazard ratio 3.3 (95% CI 2.0 to 5.3), p<0.0001. aCI, confidence interval.