T cell receptor (TCR) avidity is assumed to be a major determinant of the spatiotemporal fate and protective capacity of tumor-specific T cells. However, monitoring polyclonal T cell responses with kn
aFold increased was calculated as mean % tetramer positive cells in ALSC or TILs/ mean % tetramer positive cells from PBMCs. Frequency of T cells recognizing LMP1 or LMP2 epitopes was determined by te