CRISPRi screen to identify genes influencing TMP-SMX susceptibility.

Log2 fold change (L2FC) and the adjusted p-value (padj) and the conclusion about significance (“essential” or “costly” if |L2FC| ≥ 1, Padj 0.05) is shown for each sgRNA in treated and untreated samples. Interaction effect is also indicated, representing the differential effect of aTc induction in the presence of TMP-SMX compared to untreated samples, and whether this is significant (“yes” if |L2FC| ≥ 1, Padj (XLSX)