Crystal Structure and Solution State Characterization of Lithium (<i>S</i>)‑(1-(Bis(2-methoxyethyl)amino)-3-methylbutan-2-yl)(methyl)amide

The solid state structure of lithiated (S)-N1,N1-bis­(2-methoxyethyl)-N2,3-dimethylbutane-1,2-diamine, which is a chiral amide base synthesized from (S)-valine was determined by single-crystal X-ray diffraction. The complex in solution state is also characterized by a variety of NMR experiments including diffusion-ordered NMR spectroscopy (DOSY) with diffusion coefficient-formula weight correlation analyses and other one- and two-dimensional NMR techniques by dissolving the crystal in toluene-d8. The crystallography and NMR results suggest that the chiral amide is dimeric in both solid and solution states.