Dynamic gene regulatory networks of human myeloid differentiation [RNA-seq_siRNA]

We utilize gene expression and open chromatin footprinting data to build a gene regulatory network of key transcription factors that capture the cell and time-specific regulatory programs specified during human myeloid differentiation. RNA-seq profiling of undifferentiated HL-60, differentiating macrophage, neutrophil, monocyte, following siRNA control and siPU.1 treatment for 24 hours.