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Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naive Diabetic Human iPSC Potentiate Efficient Revascularization of Ischemic Retina

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NIAID Data Ecosystem2026-03-14 收录
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We propose that reprogramming of patient donor cells to tankyrase inhibitor-regulated naive hiPSC (N-hiPSC) improves the functionality of differentiated progenitors for subsequent regenerative therapies, and more effectively erases donor epigenetic aberrations sustained from chronic diseases such as diabetes . Overall design: LIF-3i naïve reversion of conventional, primed hiPSC lines

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2023-01-11
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