Crystal structure of PROTAC CFT-1297 in complex with CRBN-midi and BRD4(BD2)
收藏Protein Data Bank Japan2024-10-30 更新2026-06-30 收录
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Crystal structure of PROTAC CFT-1297 in complex with CRBN-midi and BRD4(BD2) Descriptor: (3~{S})-3-[7-[1-[7-[4-[6-(4-chlorophenyl)-1-methyl-spiro[[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4,1'-cyclopropane]-8-yl]pyrazol-1-yl]heptyl]piperidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]piperidine-2,6-dione, Bromodomain-containing protein 4, Protein cereblon, ... Authors: Darren, D, Ramachandran, S, Kroupova, A, Zollman, D, Ciulli, A. Deposit date: 2024-01-17 Release date: 2024-09-25 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders. Nat Commun, 15, 2024
创建时间：
2024-01-17
