Replication Data for: A multiscale model of ascending thoracic aortic aneurysm development in Marfan syndrome for in silico trials

This dataset contains a MATLAB implementation of a computational model to predict multiscale growth and remodeling of ascending thoracic aortic aneurysms in Marfan syndrome. The model contains a tissue-scale mechanical description of the aneurysm and a cell-scale protein signaling and gene regulatory network for the cells in the aortic wall (smooth muscle cells, fibroblasts, and endothelial cells). The model was calibrated and validated using murine experimental data, and allows to perform in silico trials to predict changes in aneurysm rupture risk upon perturbation of the nodes in the cell-scale model.