The expression signatures of circRNA in MCT-induced pulmonary arterial hypertension rat

To investigate the underlying mechanism of pulmonary hypertension, the model of monocrotaline (MCT)-treated pulmonary arterial hypertension (PAH) rats were constructed to detect the differentially expressed profile of circRNAs in lung tissue of PAH rat. The whole genome microarray expression profiling analysis as a discovery platform have been employed to identify genes difference.为探究肺动脉高压的潜在发病机制，本研究构建了经野百合碱（monocrotaline, MCT）诱导的肺动脉高压（pulmonary arterial hypertension, PAH）大鼠模型，以检测PAH大鼠肺组织中环状RNA（circRNAs）的差异表达谱。本研究采用全基因组微阵列表达谱分析作为发现平台，用于鉴定差异表达基因。