Comparative Analysis of Antifungal Mechanism of Lauryl betaine in the Human Fungal Pathogens Cryptococcus neoformans and Malassezia restricta. Comparative Analysis of Antifungal Mechanism of Lauryl betaine in the Human Fungal Pathogens Cryptococcus neoformans and Malassezia restricta

Purpose: Understanding the mechanism of action of lauryl betaine against Cryptococcus neoformans and Malassezia restricta. Methods: The transcriptome profile of the lauryl betaine-treated cells compared to that of untreated cells were generated by RNA-seq Illumina Hiseq. Results: A number of genes were differentially expressed in the lauryl betaine-treated cells, which include genes involved in ergosterol biosynthetic pathway. Overall design: Transcriptome of lauryl betaine-treated M. restricta cells (3 mg/ml) vs. Transcriptome of untreated M. restricta cells. Transcriptome of lauryl betaine-treated C. neoformans cells (4.5, 9.0 ug/ml) vs. Transcriptome of untreated C. neoformans cells.