BMDCS UCSF Analysis of QCT Substudy Dataset in Bone Mineral Density in Childhood Study

UCSF analysis of Qualitative CT (QCT) scans performed at baseline and Visits 03 and 06 for the QCT Substudy
Study Description
A multi-center, six year longitudinal study examining bone accretion in a racially diverse cohort of 2014 healthy boys and girls ages 5-20 years at 5 clinical centers in the US. The BMDCS cohort included children with height, weight, and body mass index (BMI) between the 3rd and 97th percentile and with no previous or current conditions that might affect bone acquisition. Recruitment occurred in two phases: 1554 subjects ages 6 to 17 years were enrolled during 2002-2003; during 2006-2007 younger (5y) and older (19y) subjects were enrolled to extend the reference percentiles to ages 5-20 years. The second wave of participants were followed for 2 years.  Annual assessments included linear growth, weight gain, pubertal maturation, nutritional status, exercise, bone mineral density (DXA by Hologic) and bone age comprised the main study measures. A subset of patients underwent pQCT and qCT.  The reference curves generated by this carefully executed study are the gold standard for normal bone accrual.
Healthy children 5 to 20 years of age