Crystal structure of IRAK4 in complex with compound 12
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Crystal structure of IRAK4 in complex with compound 12 Descriptor: 4-{[(3R)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide, Interleukin-1 receptor-associated kinase 4 Authors: Han, S, Chang, J.S. Deposit date: 2017-01-14 Release date: 2017-05-24 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J. Med. Chem., 60, 2017
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2017-01-14
