New Insights into Human 17β-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor
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https://figshare.com/articles/dataset/New_Insights_into_Human_17_-Hydroxysteroid_Dehydrogenase_Type_14_First_Crystal_Structures_in_Complex_with_a_Steroidal_Ligand_and_with_a_Potent_Nonsteroidal_Inhibitor/3482606
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资源简介：
17β-HSD14 is
a SDR enzyme able to oxidize estradiol and 5-androstenediol
using NAD+. We determined the crystal structure of this
human enzyme as the holo form and as ternary complexes with estrone
and with the first potent, nonsteroidal inhibitor. The structures
reveal a conical, rather large and lipophilic binding site and are
the starting point for structure-based inhibitor design. The two natural
variants (S205 and T205) were characterized and adopt a similar structure.
创建时间：
2016-07-26
