Setdb1

Enables DNA binding activity; histone H3K9 methyltransferase activity; and promoter-specific chromatin binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin formation. Acts upstream of or within bone development; inner cell mass cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1-cell stage embryo; central nervous system; heart; long bone; and oocyte. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]

激活 DNA 结合活性；组蛋白 H3K9 甲基转移酶活性；以及启动子特异性染色质结合活性。通过双链 DNA 中间体参与单链病毒 RNA 复制的负调控，以及 DNA 甲基化依赖性异染色质形成的正调控。在骨骼发育；内细胞团细胞增殖；以及 RNA 聚合酶 II 转录的负调控中发挥上游作用或位于其中。定位于细胞核内。在多个结构中表达，包括 1 细胞期胚胎；中枢神经系统；心脏；长骨；和卵母细胞。人类同源基因与自闭症和精神肺癌相关。与人类 SETDB1（SET 结构域分叉组蛋白赖氨酸甲基转移酶 1）同源。[由基因组资源联盟提供，2024年11月]