Model-simulated values of receptor occupancy for the conjugated-IL2 species and free-IL2 derived from NKTR-214 after a single dose administration.
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1-PEG-IL2 and 2-PEG-IL2 are present at significantly higher levels in plasma than IL2. Experimentally, free-IL2 from NKTR-214 is not detectable. The calculation indicates that individually and in sum, the active conjugated-IL2 from NKTR-214 occupy IL2Rβγ to greater extent than IL2Rαβγ.
创建时间：
2017-07-05
