RNA-seq analyses of livers from DEN/CCl4-treated Nod2f/f and Nod2 -KO mice

Chronic inflammatory response, DNA damage and subsequent genomic instability are hallmarks of carcinogens-induced HCC . We performed RNA-seq analyses of livers from DEN/CCl4-treated Nod2f/f and Nod2-KO malemice. We collectively demonstrate that hepatic NOD2 knockout attenuates the inflammatory response and DNA damage in DEN/CCl4-induced HCC model.