ANGPT2

This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]

本基因隶属于血管生成素家族的生长因子。由该基因编码的蛋白质为血管生成素1的拮抗剂，血管生成素1和血管生成素2均为内皮细胞TEK受体酪氨酸激酶的配体。血管生成素2在多种炎症性疾病中上调，并涉嫌直接调控与炎症相关的信号通路。编码的蛋白质影响胚胎发生和肿瘤发生过程中的血管生成，破坏血管生成素1的血管重塑能力，并可能诱导内皮细胞凋亡。该基因作为急性呼吸窘迫综合征的预后生物标志物。[由RefSeq提供，2020年8月]