DNA replication occurs in a defined temporal order known as the replication-timing (RT) program. RT is regulated during development in discrete chromosomal units, coordinated with transcriptional acti
Proof-of-concept for a massively parallel single-cell version of the Hi-C protocol Overall design: Single-cell Hi-C Raw data for GSM2254215, GSM2254216, GSM2254218, GSM2254219 and GSM2438426 were subm
PARP does have an essential role in the regulation of global EBV episome chromatin structure. We have functionally characterized the effect of PARP enzymatic inhibition on total episomal structure and
In this experiment, we sought to identify how topological organization changes at HoxA cluster in WT, MAZ HoxA(Δ5|6) and CTCF (Δ5|6:6|7) cells during differentiation of mouse embryonic stem cells (ESC
