The protein moonlighting dominates the phenotypic divergence of the Sef1 transcriptional regulatory networks in yeasts

We report the ChIP-seq profiling of a transcriptional factor Sef1 in Sccharomyces cerevisiae, and show that ScSef1 targets many TCA cycle and many others genes but has very limited regulatory effects to these target genes.本研究报道了酿酒酵母（Saccharomyces cerevisiae）中转录因子Sef1的染色质免疫共沉淀测序（ChIP-seq）图谱分析，并证实ScSef1可靶向大量三羧酸（TCA）循环相关基因及其他多种基因，但对这些靶基因的调控作用极为有限。