Gene expression profiling of retrovirus PDGFB-induced glioma

We performed gene expression profilings of platelet-derived growth factor subunit B (PDGFB)-induced mouse glioma to compare the differential transcriptome profiles between Ctrl-T tumor cells and Olig2cKO tumor cells. Expression profiling of Ctrl-T and Olig2cKO brain tumor (glioma) cells, normal oligodendrocyte progenitor cells (OPCs), normal astrocytes, and normal brain cortex by high-throughput sequencing.本研究对血小板衍生生长因子亚基B (PDGFB) 诱导的小鼠胶质瘤开展基因表达谱分析，旨在对比Ctrl-T肿瘤细胞与Olig2条件性敲除 (Olig2cKO) 肿瘤细胞之间的差异转录组谱。本研究通过高通量测序，对Ctrl-T组与Olig2cKO组脑肿瘤（胶质瘤）细胞、正常少突胶质细胞前体细胞 (oligodendrocyte progenitor cells, OPCs)、正常星形胶质细胞以及正常大脑皮层样本进行表达谱分析。