Neuropeptide SP protects against colitis and linked anxiety-like behavior via gut microbiota and metabolite inositol: A multi-omics analysis of the gut-brain axis

The gut-brain axis facilitates two-way communication between gut inflammation and psychiatric comorbidities associated with inflammatory bowel disease (IBD). In this study, we examined the neuroprotective effects of the neuropeptide substance P (SP) on colitis. Taking into account the interactions between the intestinal microbiota and host metabolism, along with the influence of microbiota-derived metabolites on gut-brain signaling, we conducted an untargeted metabolomic analysis.