Code and data from: No evidence for squaring the survival curve; lifespan-extending treatments increase variation in age-at-death

Geroscience has the goal of extending lifespan through geroprotective interventions. These interventions are typically imparted on groups, with their efficacy judged by increases in the average age-at-death. A more equitable outcome, which looks beyond the average, is to attain a long life for all individuals, such that the average age-at-death is high while variability is low. This goal of increasing the mean while reducing variation is sometimes referred to as “squaring the survival curve”. A recent meta-analysis of vertebrate data found that dietary restriction (DR) and the DR-mimetic, rapamycin, generally increase the average age-at-death, while metformin (also considered a DR-mimetic) is less effective. We have re-analysed this recently published data to study the effects of lifespan-extending treatments on variation in the age-at-death. On average, all three treatments increase the variance in the age-at-death, but not the coefficient of variation (i.e., standard-deviation relativ..., , # Code and data from: No evidence for squaring the survival curve; lifespan-extending treatments increase variation in age-at-death Dataset DOI: [10.5061/dryad.dv41ns2c6](https://doi.org/10.5061/dryad.dv41ns2c6) ## Description of the data and file structure \######README###### Analysis.Rmd - code to download data and for all data processing and statistical analyses Data published in Ivimey‐Cook, E.R., Sultanova, Z., and Maklakov, A.A., 2025. Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis. Aging Cell, p.e70131 Data downloaded from [https://doi.org/10.5281/zenodo.15673918](https://doi.org/10.5281/zenodo.15673918) Once downloaded using the code in Analysis.Rmd, the analyses are performed on analysis_data ### analysis_data column names (from Ivimey-Cook and Sultanova et al (2025), downloaded using Analysis): id = 1:911 unique individual ID Author list: list of authors title: title of paper Year: year paper was publ...,