Identification of novel regulators of Th17 cell pathogenicity by single-cell genomics
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Identification of novel regulators of Th17 cell pathogenicity by single-cell genomics
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2015-11-20
相关数据集
Ikzf1 lactylation regulates CD4 T cell differentiation. Ikzf1 lactylation regulates CD4 T cell differentiation
Dysregulation of Th17 differentiation was implicated in multiple inflammatory and autoimmune diseases including autoimmune uveitis. In the current study, we have provided evidence indicating that lact
NIAID Data Ecosystem60
BET bromodomain inhibition suppresses TH17-mediated pathology. Mus musculus
IL-17-producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation an
NIAID Data Ecosystem50
Data_Sheet_4_Lnc-ITSN1-2, Derived From RNA Sequencing, Correlates With Increased Disease Risk, Activity and Promotes CD4+ T Cell Activation, Proliferation and Th1/Th17 Cell Differentiation by Serving as a ceRNA for IL-23R via Sponging miR-125a in Inflammatory Bowel Disease.zip
Background: This study aimed to investigate long-non-coding RNA (lncRNA) expression profiles and the correlation of lnc-ITSN1-2 expression with disease risk, activity and inflammation, and its influen
NIAID Data Ecosystem30
Genome-wide binding of STAT3 and STAT5 under Th17 conditions (ChIP-Seq). Mus musculus
Interleukin 2 (IL-2), a cytokine linked to human autoimmune diseases, limits IL-17 production. We show that deletion of Stat3 in T cells abrogates IL-17 production and attenuates autoimmunity associat
NIAID Data Ecosystem50
Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]. Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]
CD4+ T helper 17 (Th17) cells encompass a spectrum of cell states including homeostatic cells that maintain physiological functions such as barrier integrity and pathogenic cells that drive autoimmune
NIAID Data Ecosystem40
