Transcriptome analysis by RNA sequencing after treatment with JIB-04 in colorectal cancer. Transcriptome analysis by RNA sequencing after treatment with JIB-04 in colorectal cancer

We investigate RNA sequencing analysis revealed that the JIB-04 treatment altered the expression of genes that are involved in the cell cycle, apoptosis, and DNA replication and are also related to several cancers including colorectal cancer. JIB-04 also altered the expression of genes involved in various signaling pathways such as the MAPK signaling pathway, the PI3K-Akt signaling pathway, and the Wnt signaling pathway, which is crucial for the proliferation and maintenance of colorectal cancer cells. Overall design: Examination of RNA sequencing profile in DMSO or 2µM of JIB-04 treated HCT116.