Whole-genome analysis of extended spectrum Beta-lactamase (ESBL)-producing Klebsiella pneumonia isolated from carriers admitted at orthopedic wards in Uganda and Tanzania

The plasticity of K. pneumoniae related to the acquisition of resistance and virulence genes coupled with its propensity to act as a nosocomial pathogen underscore the necessity for further investigation. We used whole genome sequencing (WGS) to unravel the sequence types (ST), antimicrobial resistance genes, virulence genes, and phylogenetic relatedness of ESBL-producing K. pneumoniae from carriage rectal swabs samples from hospitalized orthopedic patients in the tertiary referral hospitals in Uganda and Tanzania in East Africa.