Natural, nonribosomal cyclotetrapeptides have traditionally been a rich source of inspiration for design of potent histone deacetylase (HDAC) inhibitors. We recently disclosed the total synthesis and
α4β1 integrin is a cell adhesion receptor deeply involved in the migration and accumulation of leukocytes. Therefore, integrin antagonists that inhibit leukocytes recruitment are currently regarded as
ABSTRACT Pseudomonas aeruginosa is an etiologic agent of opportunistic infections mainly in immunocompromised patients. Its inherent feature of developing resistance to a wide range of antibacterial a
