ASD

Allosteric Database (ASD) provides a versatile resource for structure, function, disease and related annotation for the well-established allosteric macromolecules and allosteric modulators since 1901, data in ASD is annually updated and freely served for biologists and medicinal chemists interested in allosteric regulation mechanism and allosteric drug discovery.

搜集汇总

背景与挑战

背景概述

ASD（Allosteric Database）是一个专注于别构调节的数据库，提供自1901年以来别构大分子和调节剂的结构、功能及疾病注释，数据每年更新。2023年版本新增了hit-to-lead分子优化、别构PPI调控、人类潜在别构位点预测和双位调节剂等特性，涵盖超过10万个调节剂条目和10万多个相互作用，服务于别构机制研究和药物发现。