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Efficient and Regioselective 9-Endo Cyclization of α-Carbamoyl Radicals

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Figshare2016-02-23 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Efficient_and_Regioselective_9_i_Endo_i_Cyclization_of_Carbamoyl_Radicals/2635624
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With the promotion of Lewis acid BF3•OEt2, various N-(hex-5-enyl)-2-iodoalkanamides underwent efficient and regioselective 9-endo iodine-atom-transfer radical cyclization reactions at room temperature. The cyclized products were readily converted to the corresponding azonan-2-ones by reduction with Bu3SnH or to hexahydroindolizin-3(5H)-ones by treatment with aqueous Na2CO3 in a one-pot, two-stage manner.
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2016-02-23
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