Cerebromicrovascular Disease in Elderly with Diabetes

This dataset was collected as part of a prospective observational study to
evaluate the effects of type 2 diabetes mellitus (DM) on cerebral
vasoregulation, perfusion and functional outcomes, measured by blood flow
responses to hypocapnia and hypercapnia, Valsalva maneuver, head-up tilt, and
sit-to-stand test. The dataset comprises of observations from 69 diabetic and
control participants (aged 55 to 75 years) with continuous measurements of
cerebral blood flow using transcranial Doppler and MRI (magnetic resonance
imaging), heart rate, blood pressure, and respiratory parameters, balance,
walking, laboratory and retinopathy measures at baseline, and 41 subjects who
completed the two-years of follow-up. Regional gray, white matter and
cerebrospinal fluid volumes were quantified using a segmentation method
applied on T1- and T2- weighted images and perfusion maps, using a continuous
arterial spin labeling (CASL) images at 3 Tesla MRI. White matter integrity
was determined from fluid attenuated inversion recovery (FLAIR) and diffusion
tensor imaging (DTI) MRI. Dynamics of cerebral vasoregulation to CO2 challenge
and orthostatic stress were measured using Transcranial Doppler ultrasound
(TCD).