HIVed

To provide a comprehensive knowledgebase for curation of human proteins with differential expression during the HIV infection, replication and latency, this protein-centric database collected experimental studies of differentially regulated genes. Then the extracted genes were further mapped to their protein products, with detailed protein functional and structural annotations presented. All the curated datasets are publicly available. This database covers a wide range of experimental studies and bridges the gap between our understanding of differentially expressed human genes, protein products, and functional annotations during the HIV infection, replication and latency. In particular, the quantitative data extracted from the experimental studies is made available and displayed in the “Gene Expression Profile” tab for each entry in our database.为构建一个用于整理人类免疫缺陷病毒（HIV）感染、复制及潜伏过程中差异表达人类蛋白质的综合知识库，本以蛋白质为核心的数据库收集了差异调控基因的相关实验研究数据。随后将提取得到的基因进一步映射至对应的蛋白质产物，并附带详细的蛋白质功能与结构注释信息。所有经整理的数据集均面向公众开放获取。本数据库涵盖了广泛的实验研究范畴，填补了我们在HIV感染、复制及潜伏过程中差异表达人类基因、蛋白质产物及功能注释方面的认知空白。尤为值得一提的是，从实验研究中提取的定量数据均已公开，并在本数据库各条目对应的「基因表达谱（Gene Expression Profile）」标签页中予以展示。

搜集汇总

背景与挑战

背景概述

HIVed是一个专注于HIV感染、复制和潜伏过程中差异表达人类蛋白质的知识库，它整合了实验研究数据，将差异调控基因映射到蛋白质产物并提供详细的功能与结构注释。该数据库公开可用，支持多种搜索和浏览功能，便于用户比较基因表达并识别潜在药物靶点。