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p53 and ATF4 Mediate Distinct and Additive Mechanisms to Skeletal Muscle Atrophy During Limb Immobilization

ChEBI2014-11-05 更新2026-07-21 收录

骨骼肌萎缩机制

肌肉废用性分子通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-62897 数据链接链接失效反馈

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p53 and ATF4 Mediate Distinct and Additive Mechanisms to Skeletal Muscle Atrophy During Limb Immobilization

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创建时间：

2014-11-05

骨骼肌萎缩机制

肌肉疾病转录组学

BackgroundInflammation may trigger skeletal muscle atrophy induced by cancer cachexia. As a pro-inflammatory factor, interleukin-6 may cause skeletal muscle atrophy, but the underlying molecular mecha

NIAID Data Ecosystem100

NLRP3 inflammasome activation aggravates skeletal muscle atrophy in experimental model of denervation. NLRP3 inflammasome activation aggravates skeletal muscle atrophy in experimental model of denervation

骨骼肌萎缩机制

肌肉疾病病理学

The innervation of skeletal myofibers exerts a crucial influence on the maintenance of muscle tone and normal operation, but little is known concerning atrophy and its underlying mechanisms in denerva

NIAID Data Ecosystem60

DataSheet2_Delayed denervation-induced muscle atrophy in Opg knockout mice.PDF

骨骼肌萎缩机制

肌肉分子信号通路

Recent evidence has shown a crucial role for the osteoprotegerin/receptor activator of nuclear factor κ-B ligand/RANK (OPG/RANKL/RANK) signaling axis not only in bone but also in muscle tissue; howeve

NIAID Data Ecosystem40

Rattus norvegicus Transcriptome or Gene expression. Rattus norvegicus

骨骼肌萎缩机制

去神经支配转录组学

Using rat denervated skeletal muscle atrophy model and performed RNA-seq to analyze transcriptome profiling on tibialis anterior muscle at multiple time points following denervation.

NIAID Data Ecosystem70

Cellular Senescence and Disrupted Proteostasis induced by Myotube Atrophy are Prevented with Low Dose Metformin and Leucine Cocktail

骨骼肌萎缩机制

衰老相关蛋白质稳态

Skeletal muscle atrophy is dictated by the balance between protein synthesis and protein breakdown, known as proteostasis. With advanced age, muscle atrophy contributes to development of co-morbiditie

NIAID Data Ecosystem50

p53 and ATF4 Mediate Distinct and Additive Mechanisms to Skeletal Muscle Atrophy During Limb Immobilization

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