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Metal-Free Synthesis of 2‑Oxindoles via PhI(OAc)2‑Mediated Oxidative C–C Bond Formation

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Figshare2016-02-18 更新2026-04-29 收录
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The series of 3-monofunctionalized 2-oxindoles 2 were conveniently synthesized from reactions between anilide 1 and phenyliodine­(III) diacetate (PIDA) through hypervalent iodine mediated C­(sp2)–C­(sp2) bond formation followed by a subsequent deacylation reaction. This metal-free method, shown to provide direct access to an important oxindole intermediate, could be applied to the total synthesis of naturally occurring horsfiline.

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2016-02-18
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